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Synergistic Effect of Functionalized Nickel Nanoparticles and Quercetin on Inhibition of the SMMC-7721 Cells Proliferation

Guo, Dadong and Wu, Chunhui and Li, Jingyuan and Guo, Airong and Li, Qingning and Jiang, Hui and Chen, Baoan and Wang, Xuemei (2009) Synergistic Effect of Functionalized Nickel Nanoparticles and Quercetin on Inhibition of the SMMC-7721 Cells Proliferation. Nanoscale Research Letters, 4 (12). pp. 1395-1402.

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Abstract

The effect of functionalized nickel (Ni) nanoparticles capped with positively charged tetraheptylammonium on cellular uptake of drug quercetin into hepatocellular carcinoma cells (SMMC-7721) has been explored in this study via microscopy and electrochemical characterization as well as MTT assay. Meanwhile, the influence of Ni nanoparticles and/or quercetin on cell proliferation has been further evaluated by the real-time cell electronic sensing (RT-CES) study. Our observations indicate that Ni nanoparticles could efficiently improve the permeability of cancer cell membrane, and remarkably enhance the accumulation of quercetin in SMMC-7721 cells, suggesting that Ni nanoparticles and quercetin would facilitate the synergistic effect on inhibiting proliferation of cancer cells.

Item Type:Article
Subjects:Material Science > Nanochemistry
ID Code:8041
Deposited By:CSMNT
Deposited On:11 Feb 2010 08:04
Last Modified:16 Feb 2010 05:16

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