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Fabrication of Anti-human Cardiac Troponin I Immunogold Nanorods for Sensing Acute Myocardial Damage

Guo, Z. R. and Gu, C. R. and Fan, X. and Bian, Z. P. and Wu, H. F. and Yang, D. and Gu, N. and Zhang, J. N. (2009) Fabrication of Anti-human Cardiac Troponin I Immunogold Nanorods for Sensing Acute Myocardial Damage. Nanoscale Research Letters, 4 (12). pp. 1428-1433.

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Abstract

A facile, rapid, solution-phase method of detecting human cardiac troponin I for sensing myocardial damage has been described using gold nanorods-based biosensors. The sensing is demonstrated by the distinct change of the longitudinal surface plasmon resonance wavelength of the gold nanorods to specific antibody–antigen binding events. For a higher sensitivity, the aspect ratio of gold nanorods is increased up to ca 5.5 by simply adding small amount of HCl in seed-mediated growth solution. Experimental results show that the detecting limit of the present method is 10 ng/mL. Contrast tests reveal that these gold nanorods-based plasmonic biosensors hold much higher sensitivity than that of conventionally spherical gold nanoparticles.

Item Type:Article
Subjects:Biomedical Science > Nanobiotechnology
Material Science > Nanostructured materials
Material Science > Nanochemistry
ID Code:8037
Deposited By:CSMNT
Deposited On:25 Aug 2010 11:26
Last Modified:25 Aug 2010 11:26

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