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In vivo evaluation of a microneedle-based miniature syringe for intradermal drug delivery

Hafeli, Urs O. and Mokhtari, Amir and Liepmann, Dorian and Stoeber, Boris (2009) In vivo evaluation of a microneedle-based miniature syringe for intradermal drug delivery. Biomedical Microdevices, 11 (5). pp. 943-950.

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Abstract

A microfabrication process for miniature syringes is described. The MEMS syringes consist of a silicon plate with an array of hollow out-of-plane needles and a flexible poly-dimethylsiloxane (PDMS) reservoir attached to the back of the plate. The PDMS reservoir can be filled with a drug solution or microparticle suspension which is delivered into the skin simply by the pressure of a finger pushing on the miniature syringe. The efficiency of such a syringe for delivering a suspension of microparticles into skin tissue and a radiolabelled protein (albumin) solution into live mice is reported. Such microneedle devices could be used for the intradermal delivery of vaccination agents or for the systemic delivery of highly effective drugs.

Item Type:Article
Subjects:Engineering > Nanotechnology applications in mechanical engineering
ID Code:7998
Deposited By:CSMNT
Deposited On:25 Aug 2010 08:26
Last Modified:25 Aug 2010 08:26

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