Banerjee, Shashwat S. and Chen, Dong-Hwang (2009) Cyclodextrin-conjugated nanocarrier for magnetically guided delivery of hydrophobic drugs. Journal of Nanoparticle Research, 11 (8). pp. 2071-2078.
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A magnetic nanosystem that simultaneously implements the cyclodextrin–drug complexation power, bioadhesive property of gum arabic (GA) and inherent magnetic properties of Fe3O4 nanoparticles, has recently been reported. In this study, a magnetic nanocarrier was fabricated by conjugating 2-hydroxypropyl-cyclodextrin (HCD) onto the gum arabic modified magnetic nanoparticles (GAMNP). The analyses of transmission electron microscopy (TEM) and dynamic light scattering (DLS) revealed that the product had a mean diameter of 14.8 nm and a mean hydrodynamic diameter of 29.3 nm. This nanocarrier showed good loading efficiency for ketoprofen. In addition, the in vitro release profile of ketoprofen from HCD-GAMNP was characterized by an initial fast release followed by a delayed release phase. In view of the better biocompatibility and the combined properties like specific targeting, complexation ability with hydrophobic drugs makes the nanosystem an exciting prospect for drug delivery.
|Uncontrolled Keywords:||Magnetic - Nanosystem - Hydroxypropyl-cyclodextrin - Hydrophobic drug - Delivery - Ketoprofen - Nanomedicine|
|Subjects:||Biomedical Science > Nanotechnology for human health|
Biomedical Science > Nanomedicine
|Deposited On:||07 Jan 2010 14:38|
|Last Modified:||07 Jan 2010 14:38|
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