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The Acute Liver Injury in Mice Caused by Nano-Anatase TiO2

Ma, Linglan and Zhao, Jinfang and Wang, Jue and Liu, Jie and Duan, Yanmei and Liu, Huiting and Li, Na and Yan, Jingying and Ruan, Jie and Wang, Han and Hong, Fashui (2009) The Acute Liver Injury in Mice Caused by Nano-Anatase TiO2. Nanoscale Research Letters, 4 (11). pp. 1275-1285.

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Although it is known that nano-TiO2 or other nanoparticles can induce liver toxicities, the mechanisms and the molecular pathogenesis are still unclear. In this study, nano-anatase TiO2 (5 nm) was injected into the abdominal cavity of ICR mice for consecutive 14 days, and the inflammatory responses of liver of mice was investigated. The results showed the obvious titanium accumulation in liver DNA, histopathological changes and hepatocytes apoptosis of mice liver, and the liver function damaged by higher doses nano-anatase TiO2. The real-time quantitative RT-PCR and ELISA analyses showed that nano-anatase TiO2 can significantly alter the mRNA and protein expressions of several inflammatory cytokines, including nucleic factor-κB, macrophage migration inhibitory factor, tumor necrosis factor-α, interleukin-6, interleukin-1β, cross-reaction protein, interleukin-4, and interleukin-10. Our results also implied that the inflammatory responses and liver injury may be involved in nano-anatase TiO2-induced liver toxicity.

Item Type:Article
Uncontrolled Keywords:Mice - Nano-anatase TiO2 - Liver - Inflammatory cytokines - Histopathological changes
Subjects:Biomedical Science > Nanoscale biological processes
NanoSafety > Environment, health and safety aspects of nanotechnology
ID Code:7942
Deposited By:IoN
Deposited On:11 Jan 2010 15:44
Last Modified:11 Jan 2010 15:44

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