Nano Archive

Intracellular localization and cytotoxicity of spherical mesoporous silica nano- and microparticles.

He, Qianjun and Zhang, Zhiwen and Gao, Yu and Shi, Jianlin and Li, Yaping (2009) Intracellular localization and cytotoxicity of spherical mesoporous silica nano- and microparticles. Small, 5 (23). pp. 2722-2729. ISSN 1613-6829

Full text is not hosted in this archive but may be available via the Official URL, or by requesting a copy from the corresponding author.

Abstract

This work evaluates the cytotoxicity of spherical mesoporous silica (MS) nano- and microparticles and investigates the effects of particle size, concentration, biodegradation products of MS, residual surfactant, and surfactant removal by extraction and calcination on the cytotoxicity. The results from the intracellular localization of spherical MS nano- and microparticles with different sizes reveal the mechanism for their cytotoxicity and that the smaller particles in nanoscale are more easily endocytosed and consequently located within lysosomes

Item Type:Article
Subjects:Biomedical Science > Nanoscale biological processes
ID Code:7890
Deposited By:CSMNT
Deposited On:26 Dec 2009 07:24
Last Modified:21 Jan 2010 16:01

Repository Staff Only: item control page