He, Qianjun and Zhang, Zhiwen and Gao, Yu and Shi, Jianlin and Li, Yaping (2009) Intracellular localization and cytotoxicity of spherical mesoporous silica nano- and microparticles. Small, 5 (23). pp. 2722-2729. ISSN 1613-6829
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This work evaluates the cytotoxicity of spherical mesoporous silica (MS) nano- and microparticles and investigates the effects of particle size, concentration, biodegradation products of MS, residual surfactant, and surfactant removal by extraction and calcination on the cytotoxicity. The results from the intracellular localization of spherical MS nano- and microparticles with different sizes reveal the mechanism for their cytotoxicity and that the smaller particles in nanoscale are more easily endocytosed and consequently located within lysosomes
|Subjects:||Biomedical Science > Nanoscale biological processes|
|Deposited On:||26 Dec 2009 07:24|
|Last Modified:||21 Jan 2010 16:01|
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