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Mass transport effect of mesoscopic domains in the amperometric response of an electroactive species: Modeling for its applications in biomolecule detection

GONZALEZ, G and PRIANO, G and GUNTHER, M and BATTAGLINI, F (2008) Mass transport effect of mesoscopic domains in the amperometric response of an electroactive species: Modeling for its applications in biomolecule detection. Sensors and Actuators B: Chemical . ISSN 09254005 (In Press)

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Official URL: http://dx.doi.org/10.1016/j.snb.2008.11.006

Abstract

We report the numerical simulation of an electrochemical system compromising a mesoporous material placed at a close distance of a working electrode. The effect of mesoscopic domains to the amperometric response of an electroactive species by applying a cyclic voltammetry is simulated to establish the influence of different parameters on the sensitivity of this system to detect molecules able to block the pores. Alumina membranes were chosen as mesoporous material; they were modified with anti-horseradish peroxidase as model system to test the behavior predicted by the simulation. The label-free assembled electrochemical system shows a reproducible behavior and it is able to detect a 10 nM protein concentration.

Item Type:Article
Subjects:Material Science > Bio materials
Material Science > Nanochemistry
ID Code:7880
Deposited By:M T V
Deposited On:24 Dec 2009 10:25
Last Modified:24 Dec 2009 10:25

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