Vetrone, Fiorenzo and Naccache, Rafik and Juarranz de la Fuente, Angeles and Sanz-Rodríguez, Francisco and Blazquez-Castro, Alfonso and Rodriguez, Emma Martin and Jaque, Daniel and Solé, José García and Capobianco, John A. (2009) Intracellular imaging of HeLa cells by non-functionalized NaYF4 : Er3+, Yb3+ upconverting nanoparticles. nanoscale .
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We report on the efficient incorporation of non-functionalized NaYF4 : Er3+, Yb3+ nanoparticles inside HeLa live cancer cells by direct endocytosis. The efficient two-photon excited near-infrared-to-visible upconversion fluorescence of these nanoparticles is then used to obtain high-contrast intracellular fluorescence images of single cells. These images reveal a redistribution of the nanoparticles inside the cell as the incubation time increases. Thus, non-functionalized NaYF4 : Er3+, Yb3+ nanoparticles emerge as very promising fluorescence probes for real-time imaging of cellular dynamics.
|Subjects:||Biomedical Science > Nanobiotechnology|
|Deposited On:||27 Nov 2009 16:21|
|Last Modified:||27 Nov 2009 16:21|
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