Nano Archive

A monolithic polymeric microdevice for pH-responsive drug delivery

Chen, Jian and Chu, Michael and Koulajian, Khajag and Wu, Xiao Yu and Giacca, Adria and Sun, Yu (2009) A monolithic polymeric microdevice for pH-responsive drug delivery. BIOMEDICAL MICRODEVICES, 11 (6). pp. 1251-1257. ISSN 1387-2176 (Print) 1572-8781 (Online)

Full text is not hosted in this archive but may be available via the Official URL, or by requesting a copy from the corresponding author.

Official URL:


A drug-delivery microdevice integrating pH-responsive nano-hydrogel particles functioning as intelligent nano valves is described. The polymeric microdevices are monolithic without requiring peripheral control hardware or additional components for controlling drug-release rates. pH-responsive nanoparticles were synthesized and embedded into a composite membrane. The resulting pH-responsive composite membranes were integrated with PDMS micro reservoirs via a room-temperature transfer bonding technique to form the proof-of-concept microdevices. In vitro release characterization of the microdevices was conducted in which the release rate of Vitamin B12 (VB12) as a model drug increased dramatically when the local pH value was decreased from 7.4 to 4. This device concept can serve as a platform technology for intelligent drug delivery in response to various in vivo environmental signals.

Item Type:Article
Subjects:Biomedical Science > Nanobiotechnology
Biomedical Science > Nanomedicine
ID Code:7820
Deposited By:M T V
Deposited On:30 Nov 2009 15:48
Last Modified:30 Nov 2009 15:48

Repository Staff Only: item control page