Chen, Jian and Chu, Michael and Koulajian, Khajag and Wu, Xiao Yu and Giacca, Adria and Sun, Yu (2009) A monolithic polymeric microdevice for pH-responsive drug delivery. BIOMEDICAL MICRODEVICES, 11 (6). pp. 1251-1257. ISSN 1387-2176 (Print) 1572-8781 (Online)
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Official URL: http://www.springerlink.com/content/fq001w173906m7...
A drug-delivery microdevice integrating pH-responsive nano-hydrogel particles functioning as intelligent nano valves is described. The polymeric microdevices are monolithic without requiring peripheral control hardware or additional components for controlling drug-release rates. pH-responsive nanoparticles were synthesized and embedded into a composite membrane. The resulting pH-responsive composite membranes were integrated with PDMS micro reservoirs via a room-temperature transfer bonding technique to form the proof-of-concept microdevices. In vitro release characterization of the microdevices was conducted in which the release rate of Vitamin B12 (VB12) as a model drug increased dramatically when the local pH value was decreased from 7.4 to 4. This device concept can serve as a platform technology for intelligent drug delivery in response to various in vivo environmental signals.
|Subjects:||Biomedical Science > Nanobiotechnology|
Biomedical Science > Nanomedicine
|Deposited By:||M T V|
|Deposited On:||30 Nov 2009 15:48|
|Last Modified:||30 Nov 2009 15:48|
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