Nano Archive

3D microfabricated bioreactor with capillaries

Xia, Chunguang and Fang, Nicholas X. (2009) 3D microfabricated bioreactor with capillaries. BIOMEDICAL MICRODEVICES, 11 (6). pp. 1309-1315. ISSN 1387-2176 (Print) 1572-8781 (Online)

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We present in this paper the implementation of an innovative three dimensional (3D) microfabrication technology coupled with numerical simulation to enhance the mass transport in 3D cell culture. The core of this microfabrication technology is a high-resolution projection micro stereolithography (PμSL) using a spatial light modulator as a dynamic mask which enables a parallel fabrication of highly complex 3D microstructures. In this work, a set of poly (ethylene glycol) microfabricated bioreactors are demonstrated with PμSL technology. We observed both experimentally and numerically the regulation of metabolism and the growth of yeast cells by controlling the density of micro-capillaries. Further development of these 3D microfabricated bioreactors is expected to provide artificially constructed tissues for clinical applications.

Item Type:Article
Subjects:Biomedical Science > Nanobiotechnology
Biomedical Science > Nanomedicine
ID Code:7814
Deposited By:M T V
Deposited On:30 Nov 2009 16:05
Last Modified:30 Nov 2009 16:05

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