Nano Archive

Selective cytotoxic effect of ZnO nanoparticles on glioma cells

Ostrovsky, Stella and Kazimirsky, Gila and Gedanken, Aharon and Brodie, Chaya (2009) Selective cytotoxic effect of ZnO nanoparticles on glioma cells. Nano Research, 2 (11). pp. 882-890. ISSN 1998-0124 (print version) ISSN: 1998-0000 (electronic version)

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In this study we examined the cytotoxic effect of ZnO nanoparticles on various human cancer and normal cells. We found that the ZnO nanoparticles exerted a cytotoxic effect on the human glioma cell lines A172, U87, LNZ308, LN18, and LN229, whereas no cytotoxic effect was observed on normal human astrocytes. Similarly, the ZnO nanoparticles induced cell death in breast and prostate cancer cell lines while no major effect was observed in the respective normal breast and prostate cell lines. Using the fluorescent dye 2,7-dichlorofluorescein diacetate, we found that treatment of the glioma cells with ZnO nanoparticles induced a large increase in the generation of reactive oxygen species (ROS) and treatment of the cells with N-acetyl cysteine decreased the cytotoxic effect of the ZnO nanoparticles. In contrast, a smaller effect on ROS generation was observed in the normal astrocytes. These results suggest that ZnO nanoparticles may be employed as a selective cytotoxic agent for the eradication of cancer cells.

Item Type:Article
Subjects:Biomedical Science > Nanobiotechnology
NanoSafety > Environment, health and safety aspects of nanotechnology
ID Code:7806
Deposited By:M T V
Deposited On:30 Nov 2009 16:26
Last Modified:30 Nov 2009 16:26

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