Hussain, M. A. and Badshah, M. and Iqbal, M. S. and Tahir, M. N. and Tremel, W. and Bhosale, S. V. and Sher, M. and Haseeb, M. T. (2009) HPMC-Salicylate Conjugates as Macromolecular Prodrugs: Design, Characterization, and Nano-Rods Formation. Journal of Polymer Science Part A: Polymer Chemistry, 47 (16). pp. 4202-4208. ISSN 0887-624X
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Official URL: http://www3.interscience.wiley.com/journal/1225050...
Hydroxypropylmethylcellulose (HPMC) is a neutral, nonionic, acid resistant, and hydrolysable in basic medium. Keeping in view these properties, HPMC-salicylic acid conjugates, that is, macromolecular prodrugs were successfully synthesized, purified, and characterized by gel permeation chromatography, thermal analysis (TGA/DTA/DSC) and UV, FTIR, 1H NMR spectroscopic techniques. Chemical attachment (covalent) of the salicylic acid on HPMC and purity of products was verified by spectroscopic analyses. UV spectroscopy has indicated the incorporation of the drug in the conjugates after in vitro release in basic medium. Transmission electron microscopy has shown formation of nano-rods because of amphiphilic nature of products (HPMC-salicylate). All the samples synthesized were found thermally as stable as native HPMC. [Color figure can be viewed in the online issue, which is available at www.interscience.wiley.com.]
|Subjects:||Physical Science > Nanophysics|
Physical Science > Nano objects
Material Science > Nanochemistry
Material Science > Nanostructured materials
|Divisions:||Faculty of Engineering, Science and Mathematics > School of Physics|
Faculty of Engineering, Science and Mathematics > School of Chemistry
|Deposited On:||16 Nov 2009 09:39|
|Last Modified:||16 Nov 2009 09:39|
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