Nano Archive

Nanosized cancer cell-targeted polymeric immunomicelles loaded with superparamagnetic iron oxide nanoparticles

Sawant, Rishikesh M. and Sawant, Rupa R. and Gultepe, Evin and Nagesha, Dattatri and Papahadjopoulos-Sternberg, Brigitte and Sridhar, Srinivas and Torchilin, Vladimir P. (2009) Nanosized cancer cell-targeted polymeric immunomicelles loaded with superparamagnetic iron oxide nanoparticles. Journal of Nanoparticle Research, 11 (7). pp. 1777-1785.

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Official URL: http://www.springerlink.com/content/p2m33612178q02...

Abstract

Stable 30–50 nm polymeric polyethylene glycol–phosphatidylethanolamine (PEG–PE)-based micelles entrapping superparamagnetic iron oxide nanoparticles (SPION) have been prepared. At similar concentrations of SPION, the SPION-micelles had significantly better magnetic resonance imaging (MRI) T2 relaxation signal compared to ‘plain’ SPION. Freeze-fracture electron microscopy confirmed SPION entrapment in the lipid core of the PEG–PE micelles. To enhance the targeting capability of these micelles, their surface was modified with the cancer cell-specific anti-nucleosome monoclonal antibody 2C5 (mAb 2C5). Such mAb 2C5-SPION immunomicelles demonstrated specific binding with cancer cells in vitro and were able to bring more SPION to the cancer cells thus demonstrating the potential to be used as targeted MRI contrast agents for tumor imaging.

Item Type:Article
Uncontrolled Keywords:Superparamagnetic iron oxide nanoparticles - Polymeric micelles - Immunomicelles - Cancer-specific monoclonal antibody - MRI contrast agent - Nanomedicine
Subjects:Biomedical Science > Nanotechnology for human health
Biomedical Science > Nanomedicine
ID Code:7713
Deposited By:Lesley Tobin
Deposited On:31 Mar 2010 16:34
Last Modified:31 Mar 2010 16:34

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