Nano Archive

Modern nano-sized delivery systems based on lipodipeptides for treating genetic and oncological diseases

Sebyakin, Yu. and Budanova, U. and Koloskova, O. and Mironov, A. (2009) Modern nano-sized delivery systems based on lipodipeptides for treating genetic and oncological diseases. Nanotechnologies in Russia, 4 . pp. 281-289.

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Official URL: http://dx.doi.org/10.1134/S1995078009050048

Abstract

Here we report the synthesis of an array of new lipid-like nonvirus transfection mediators. The polar part of cationic amphiphiles is represented by OrnGlu, LysGlu, and ArgGlu dipeptides. The hydrophobic fragment is formed by mono- and diesters of L-glutamic acid and aliphatic saturated and nonsaturated alcohols varying in length (C8, C14, C18:1). The sizes and morphology of complexes with DNA have been determined via electron microscopy. The new transfection mediators are nontoxic and were shown to deliver genes into tumor and nontumor cells with a high efficiency comparable to that of next-generation commercial preparations.

Item Type:Article
Additional Information:10.1134/S1995078009050048
ID Code:7632
Deposited By:Prof. Alexey Ivanov
Deposited On:11 Nov 2009 07:54
Last Modified:11 Nov 2009 08:00

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