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Human skin penetration of sunscreen nanoparticles: In-vitro assessment of a novel micronized zinc oxide formulation

Cross, Sheree E. and Innes, Brian and Roberts, Michael S. and Tsuzuki, Takuya and Robertson, Terry A. and McCormick, Paul (2007) Human skin penetration of sunscreen nanoparticles: In-vitro assessment of a novel micronized zinc oxide formulation. SKIN PHARMACOLOGY AND PHYSIOLOGY, 20 (3). pp. 148-154.

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Abstract

The extent to which topically applied solid nanoparticles can penetrate the stratum corneum and access the underlying viable epidermis and the rest of the body is a great potential safety concern. Therefore, human epidermal penetration of a novel, transparent, nanoparticulate zinc oxide sunscreen formulation was determined using Franz-type diffusion cells, 24-hour exposure and an electron microscopy to verify the location of nanoparticles in exposed membranes. Less than 0.03% of the applied zinc content penetrated the epidermis ( not significantly more than the zinc detected in receptor phase following application of a placebo formulation). No particles could be detected in the lower stratum corneum or viable epidermis by electron microscopy, suggesting that minimal nanoparticle penetration occurs through the human epidermis. Copyright (c) 2007 S. Karger AG, Basel

Item Type:Article
Uncontrolled Keywords:nanoparticle safety; risk assessment; transdermal delivery
Subjects:NanoSafety > Environment, health and safety aspects of nanotechnology
ID Code:762
Deposited By:Farnush Anwar
Deposited On:15 Dec 2008 12:53
Last Modified:13 Jan 2009 10:47

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