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CRP determination based on a novel magnetic biosensor

Meyer, Martin H. F. and Hartmann, Markus and Krause, Hans-Joachim and Blankenstein, Gert and Mueller-Chorus, Birgit and Oster, Juergen and Miethe, Peter and Keusgen, Michael (2007) CRP determination based on a novel magnetic biosensor. BIOSENSORS & BIOELECTRONICS, 22 (6). pp. 973-979.

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The c-reactive protein (CRP) is a very significant human blood marker for inflammatory processes and is routinely determined for many clinical purposes. The widespread and well established detection method for this similar to 115 kDa hepatic protein is the high-sensitivity ELISA assay (hsCRP-ELISA) in blood serum. New approaches in medical CRP diagnosis (e.g. for CVD, inflammatory bowel disease) require rapid quantification in native matrices. A novel CRP determination method based on magnetic detection is described and tested for human blood serum, saliva and urine. The detection principle is based on two different anti-CRP antibodies (monoclonal, IgG) for CRP trapment and labelling. The linear detection range of this immunosensor ranged from 25 ng/ml to 2.5 mu g/ml and is therefore much more sensitive than typical hsCRP-ELISA-assays. (c) 2006 Elsevier B.V. All rights reserved.

Item Type:Article
Uncontrolled Keywords:c-reactive protein (CRP); magnetic detection; immumosensor; inflammation; CVD; IBD
Subjects:Biomedical Science > Nanobiotechnology
Biomedical Science > Nanotechnology for human health
Biomedical Science > Nanomedicine
ID Code:761
Deposited By:Farnush Anwar
Deposited On:12 Dec 2008 11:30
Last Modified:12 Dec 2008 11:30

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