Rashid, H and Shah, S. Q. (2003) Rapid preparation and easy quality control procedures for (99)mTc-Tin-Nano colloid: A lymphoscintigraphic agent. JOURNAL OF THE CHINESE CHEMICAL SOCIETY, 50 (6). pp. 1159-1163. ISSN 0009-4536
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Tc-99m-Tin-nano colloid is a radiopharmaceutical that can be useful in evaluation of the patients with breast cancer. The current method for preparation requires a lengthy boiling water bath procedure, and the recommended quality control procedure is cumbersome and time consuming. Using a microwave oven, the heating time necessary to provide a maximum labeling efficiency has been reduced to 10 second. A new mini paper chromatography (MPC) system has been developed to analyze the radiochemical purity (RCP) of the labeled preparation involving two different developing solvents. The recommended thin layer chromatography (TLC) system involving the use of an Al2O3 coated plate requires an average time for drying and development of 34.5 +/- 0.44 min (n = 30) to complete, whereas the new MPC system has an average developing time of 2.1 +/- 0.2 min (n = 20). For RCP values the MPC and TLC methods are correlated closely (r = 0.94). The combined use of the microwave oven heating method and over quick quality control system will facilitate the rapid emergency use of Tc-99m-Tin-nano colloid.
|Subjects:||Physical Science > Nanophysics|
Physical Science > Nano objects
Material Science > Nanochemistry
Material Science > Nanostructured materials
|Divisions:||Faculty of Engineering, Science and Mathematics > School of Physics|
Faculty of Engineering, Science and Mathematics > School of Chemistry
|Deposited On:||12 Nov 2009 04:13|
|Last Modified:||12 Nov 2009 04:13|
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