Nano Archive

Micromechanical properties of human trabecular bone: A hierarchical investigation using nanoindentation

Norman, Jonathan and Shapter, Joe G. and Short, Ken and Smith, Lachlan J. and Fazzalari, Nicola L. (2008) Micromechanical properties of human trabecular bone: A hierarchical investigation using nanoindentation. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 87A (1). pp. 196-202.

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Official URL: http://www3.interscience.wiley.com/journal/1178666...

Abstract

The ability to assess the risk of fracture, evaluate new therapies, predict implant success and assess the influence of bone remodeling disorders requires specific measurement of local bone micromechanical properties. Nanoindentation is an established tool for assessing the micromechanical properties of hard biological tissues. In this study, elastic modulus and hardness were quantified using nanoindentation for human trabccular bone from the intertrochanteric region of the proximal femur. These properties were demonstrated to be heterogeneous and highly correlated at the intraspicule, interspicule, and interspecimen levels. The results of this study have important implications for current understanding of structure-function relationships throughout the trabecular bone structural hierarchy. (C) 2007 Wiley Periodicals, Inc.

Item Type:Article
Uncontrolled Keywords:trabecular bone; structural hierarchy; micromechanical properties; nanoindentation
Subjects:Analytical Science > Microscopy and probe methods
Analytical Science > Metrology and standards in nanotechnology
ID Code:710
Deposited By:SPI
Deposited On:19 Jan 2009 12:29
Last Modified:19 Jan 2009 12:29

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