Nano Archive

Fabrication, characterization and long-term in vitro release of hydrophilic drug using PHBV/HA composite microspheres

Wang, Yingjun and Wang, Xudong and Wei, Kun and Zhao, Naru and Zhang, Shuhua and Chen, Jingdi (2007) Fabrication, characterization and long-term in vitro release of hydrophilic drug using PHBV/HA composite microspheres. Materials Letters, 61 (4-5). 1071 - 1076.

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Official URL: http://www.sciencedirect.com/science/article/B6TX9...

Abstract

In this paper, we fabricated polyhydroxybutyrate-co-hydroxyvalerate (PHBV)/Hydroxyapatite (HA) composite microspheres as a long-term drug delivery system. The characterization and in vitro release properties of the system were investigated. It was observed that the PHBV/HA composite microspheres showed very low initial burst that could be neglected, owing to the high affinity and absorbability of nano-HA particles, and the sustained release lasted more than 10 weeks. The in vitro release rate was controlled by diffusion rate of drugs from polymer matrices, and the release profile can be expressed by the Higuchi equation. From our work, it indicated that PHBV/HA composite microsphere could be a promising long-term drug release system.

Item Type:Article
Uncontrolled Keywords:Hydroxyapatite (nano-HA); polyhydroxybutyrate-co-hydroxyvalerate (PHBV); Nanoparticles; Composite microsphere; Controlled release
Subjects:Material Science > Nanofabrication processes and tools
Material Science > Nanostructured materials
ID Code:6751
Deposited By:SPI
Deposited On:09 Feb 2010 09:33
Last Modified:09 Feb 2010 09:33

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