Nano Archive

Effect of nano- and micro-hydroxyapatite/chitosan-gelatin network film on human gastric cancer cells

Li, Junjie and Yin, Yuji and Yao, Fanglian and Zhang, Lili and Yao, Kangde (2008) Effect of nano- and micro-hydroxyapatite/chitosan-gelatin network film on human gastric cancer cells. Materials Letters, 62 (17-18). 3220 - 3223.

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Official URL: http://www.sciencedirect.com/science/article/B6TX9...

Abstract

After a tumorotomy operation, desirable biomaterials should be able to inhibit the cancer cell growth around the defects. In this article, a comparative study of human gastric cancer SGC-7901 cells behavior on the micro-hydorxyapatite (mHA) and nano-hydroxyapatite (nHA) surface layer was carried out. nHA crystalline was biomineralized on the chitosan-gelatin network films and the mean size of the nHA crystalline was 17–25 nm evaluated by X-ray diffraction (XRD) and transmission electron microscope (TEM), while the sintered mHA with average size 5 μm was deposited on the films directly. The surface characteristic observed by scanning electron microscope (SEM). MTT assay of SGC-7901 cells cultured on nHA and mHA surface suggested that nHA crystalline can effectively inhibit the proliferation performance of SGC-7901 cells. The size of HA crystalline has important influence on the adhesion performance and morphology of SGC-7901 cells.

Item Type:Article
Uncontrolled Keywords:Nano-hydroxyapatite; Micro-hydroxyapatite; Chitosan; Gelation; Anticancer
Subjects:Biomedical Science > Nanotechnology for human health
Material Science > Bio materials
Material Science > Nanostructured materials
Biomedical Science > Nanomedicine
ID Code:6646
Deposited By:SPI
Deposited On:10 Feb 2010 09:45
Last Modified:10 Feb 2010 09:45

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