Zhou, Lin and Dong, Chao and Wei, Shao Hua and Feng, Yu Ying and Zhou, Jia Hong and Liu, Ji Hua (2009) Water-soluble soft nano-colloid for drug delivery. Materials Letters, 63 (20). 1683 - 1685.
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Official URL: http://www.sciencedirect.com/science/article/B6TX9...
Photodynamic therapy (PDT) has been proved to be highly effective in the treatment of different types of cancer. A novel nano-colloid based drug carrier for PDT of elsinochrome A (EA), a hydrophobic photosensitizer, was prepared using single 3-aminopropyltriethoxysilane (APTES) which is traditionally only used as surface modification reagent. The resulting nano-colloid immobilized photosensitizers provide good water solubility and photostability. In addition, EANC preserve the key step of photogeneration of singlet oxygen, necessary for photodynamic action. Moreover, significant damage to calf thymus DNA was observed upon irradiation with light. Thus, the potential of using nano-colloid as drug carriers for photodynamic therapy has been demonstrated.
|Uncontrolled Keywords:||Nanomaterials; Sol–gel preparation; Elsinochrome A; Water solubility; Photostability; Photodynamic efficacy|
|Subjects:||Biomedical Science > Nanotechnology for human health|
Biomedical Science > Nanomedicine
|Deposited On:||10 Feb 2010 17:31|
|Last Modified:||10 Feb 2010 17:31|
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