Reinscheid, Uwe M. (2009) Accelerated Hydrolysis of Aspirin Using Alternating Magnetic Fields. Nanoscale Research Letters, 4 (8). pp. 854-857.
Official URL: http://www.springerlink.com/content/bj711482p65562...
The major problem of current drug-based therapy is selectivity. As in other areas of science, a combined approach might improve the situation decisively. The idea is to use the pro-drug principle together with an alternating magnetic field as physical stimulus, which can be applied in a spatially and temporarily controlled manner. As a proof of principle, the neutral hydrolysis of aspirin in physiological phosphate buffer of pH 7.5 at 40Â Â°C was chosen. The sensor and actuator system is a commercially available gold nanoparticle (NP) suspension which is approved for animal usage, stable in high concentrations and reproducibly available. Applying the alternating magnetic field of a conventional NMR magnet system accelerated the hydrolysis of aspirin in solution.
|Uncontrolled Keywords:||Gold nanoparticle - Magnetic field - Relaxation - Hydrolysis - Pro-drug|
|Subjects:||Physical Science > Nanomagnetics|
Biomedical Science > Nanomedicine
|Deposited On:||28 Jul 2009 10:04|
|Last Modified:||28 Jul 2009 10:04|
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