Nano Archive

Accelerated Hydrolysis of Aspirin Using Alternating Magnetic Fields

Reinscheid, Uwe M. (2009) Accelerated Hydrolysis of Aspirin Using Alternating Magnetic Fields. Nanoscale Research Letters, 4 (8). pp. 854-857.

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Official URL: http://www.springerlink.com/content/bj711482p65562...

Abstract

The major problem of current drug-based therapy is selectivity. As in other areas of science, a combined approach might improve the situation decisively. The idea is to use the pro-drug principle together with an alternating magnetic field as physical stimulus, which can be applied in a spatially and temporarily controlled manner. As a proof of principle, the neutral hydrolysis of aspirin in physiological phosphate buffer of pH 7.5 at 40 °C was chosen. The sensor and actuator system is a commercially available gold nanoparticle (NP) suspension which is approved for animal usage, stable in high concentrations and reproducibly available. Applying the alternating magnetic field of a conventional NMR magnet system accelerated the hydrolysis of aspirin in solution.

Item Type:Article
Uncontrolled Keywords:Gold nanoparticle - Magnetic field - Relaxation - Hydrolysis - Pro-drug
Subjects:Physical Science > Nanomagnetics
Biomedical Science > Nanomedicine
ID Code:6519
Deposited By:SPI
Deposited On:28 Jul 2009 10:04
Last Modified:28 Jul 2009 10:04

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