Nano Archive

Optical detection of ion-channel-induced proton transport in supported phospholipid bilayers

Yang, Tsung-Han (Calvin) and Yee, Chanel K. and Amweg, Meri L. and Singh, Seema and Kendall, Eric L. and Dattelbaum, Andrew M. and Shreve, Andrew P. and Brinker, C. Jeffrey and Parikh, Atul N. (2007) Optical detection of ion-channel-induced proton transport in supported phospholipid bilayers. NANO LETTERS, 7 (8). pp. 2446-2451.

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Official URL: http://pubs.acs.org/doi/abs/10.1021/nl071184j

Abstract

The integration of ion-channel transport functions with responses derived from nanostructured and nanoporous silica mesophase materials is demonstrated. Patterned thin-film mesophases consisting of alternating hydrophilic nanoporous regions and hydrophobic nanostructured regions allow for spatially localized proton transport via selective dimerization of gramicidin in lipid bilayers formed on the hydrophilic regions. The adjoining hydrophobic mesostructure doped with a pH sensitive dye reports the transport. The ease of integrating functional membranes and reporters through the use of patterned mesophases should enable high throughput studies of membrane transport.

Item Type:Article
Subjects:Analytical Science > Nanotechnology for sensing and actuating
Biomedical Science > Nanoscale biological processes
Material Science > Nanostructured materials
ID Code:6353
Deposited By:IoN
Deposited On:07 Aug 2009 09:37
Last Modified:07 Aug 2009 09:37

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