Yang, Tsung-Han (Calvin) and Yee, Chanel K. and Amweg, Meri L. and Singh, Seema and Kendall, Eric L. and Dattelbaum, Andrew M. and Shreve, Andrew P. and Brinker, C. Jeffrey and Parikh, Atul N. (2007) Optical detection of ion-channel-induced proton transport in supported phospholipid bilayers. NANO LETTERS, 7 (8). pp. 2446-2451.
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Official URL: http://pubs.acs.org/doi/abs/10.1021/nl071184j
The integration of ion-channel transport functions with responses derived from nanostructured and nanoporous silica mesophase materials is demonstrated. Patterned thin-film mesophases consisting of alternating hydrophilic nanoporous regions and hydrophobic nanostructured regions allow for spatially localized proton transport via selective dimerization of gramicidin in lipid bilayers formed on the hydrophilic regions. The adjoining hydrophobic mesostructure doped with a pH sensitive dye reports the transport. The ease of integrating functional membranes and reporters through the use of patterned mesophases should enable high throughput studies of membrane transport.
|Subjects:||Analytical Science > Nanotechnology for sensing and actuating|
Biomedical Science > Nanoscale biological processes
Material Science > Nanostructured materials
|Deposited On:||07 Aug 2009 09:37|
|Last Modified:||07 Aug 2009 09:37|
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