Nano Archive

Reducing facet nucleation during algorithmic self-assembly

Chen, Ho-Lin and Schulman, Rebecca and Goel, Ashish and Winfree, Erik (2007) Reducing facet nucleation during algorithmic self-assembly. NANO LETTERS, 7 (9). pp. 2913-2919.

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Algorithmic self-assembly, a generalization of crystal growth, has been proposed as a mechanism for bottom-up fabrication of complex nanostructures and autonomous DNA computation. In principle, growth can be programmed by designing a set of molecular tiles with binding interactions that enforce assembly rules. In practice, however, errors during assembly cause undesired products, drastically reducing yields. Here we provide experimental evidence that assembly can be made more robust to errors by adding redundant tiles that “proofread” assembly. We construct DNA tile sets for two methods, uniform and snaked proofreading. While both tile sets are predicted to reduce errors during growth, the snaked proofreading tile set is also designed to reduce nucleation errors on crystal facets. Using atomic force microscopy to image growth of proofreading tiles on ribbon-like crystals presenting long facets, we show that under the physical conditions we studied the rate of facet nucleation is 4-fold smaller for snaked proofreading tile sets than for uniform proofreading tile sets.

Item Type:Article
Subjects:Material Science > Bio materials
Material Science > Nanostructured materials
ID Code:6346
Deposited By:IoN
Deposited On:07 Aug 2009 09:45
Last Modified:07 Aug 2009 09:45

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