Nano Archive

Cationic comb-type copolymers for boosting DNA-fueled nanomachines

Choi, Sung Won and Makita, Naoki and Inoue, Satoru and Lesoil, Charles and Yamayoshi, Asako and Kano, Arihiro and Akaike, Toshihiro and Maruyama, Atsushi (2007) Cationic comb-type copolymers for boosting DNA-fueled nanomachines. NANO LETTERS, 7 (1). pp. 172-178.

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For the better applications and developments of DNA nanomachines, their responding kinetics, output, and sequence-selectivity need to be improved. Furthermore, the DNA nanomachines currently have several limitations in operating conditions. Here we show that a simple addition of a cationic comb-type copolymer, poly(l-lysine)-graft-dextran, produces the robust and quick responses of DNA nanomachines under moderate conditions including physiologically relevant conditions even at very low strand concentrations (nanomoles per liter range) through hybrid stabilization and DNA strand exchange acceleration.

Item Type:Article
Subjects:Physical Science > Nano objects
Biomedical Science > Nanobiotechnology
Material Science > Nanochemistry
ID Code:6302
Deposited By:IoN
Deposited On:07 Aug 2009 11:11
Last Modified:07 Aug 2009 11:11

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