Nano Archive

A paramagnetic nanoprobe to detect tumor cell death using magnetic resonance imaging

Neves, Andre A. and Krishnan, Anant S. and Kettunen, Mikko I. and Hu, De-En and de Backer, Maaike M. and Davletov, Bazbek and Brindle, Kevin M. (2007) A paramagnetic nanoprobe to detect tumor cell death using magnetic resonance imaging. NANO LETTERS, 7 (5). pp. 1419-1423.

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Official URL: http://pubs.acs.org/doi/abs/10.1021/nl070126v

Abstract

A 110 kDa (ca. 5 nm in diameter) bivalent paramagnetic nanoprobe for detecting cell death using magnetic resonance imaging (MRI) is described, in which two biotinylated C2A domains of the protein synaptotagmin-I were complexed with a single avidin molecule, which had been labeled with gadolinium chelates. This nanoprobe bound with high affinity and specificity to the phosphatidylserine exposed by dying cells and was demonstrated to allow MRI detection of apoptotic tumor cells in vitro.

Item Type:Article
Subjects:Biomedical Science > Nanoscale biological processes
Analytical Science > Nanotechnology for sensing and actuating
Physical Science > Nano objects
ID Code:6297
Deposited By:IoN
Deposited On:07 Aug 2009 11:22
Last Modified:07 Aug 2009 11:22

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