Nano Archive

Labeling of mesenchymal stem cells by bioconjugated quantum dots

Shah, Lhranti S. and Clark, Paul A. and Moioli, Eduardo K. and Stroscio, Michael A. and Mao, Jeremy J. (2007) Labeling of mesenchymal stem cells by bioconjugated quantum dots. NANO LETTERS, 7 (10). pp. 3071-3079.

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Official URL: http://pubs.acs.org/doi/abs/10.1021/nl071547f

Abstract

Long-term labeling of stem cells during self-replication and differentiation benefits investigations of development and tissue regeneration. We report the labeling of human mesenchymal stem cells (hMSCs) with RGD-conjugated quantum dots (QDs) during self-replication, and multilineage differentiations into osteogenic, chondrogenic, and adipogenic cells. QD-labeled hMSCs remained viable as unlabeled hMSCs from the same subpopulation. These findings suggest the use of bioconjugated QDs as an effective probe for long-term labeling of stem cells.

Item Type:Article
Subjects:Biomedical Science > Nanotechnology for animal health
Biomedical Science > Nanomedicine
ID Code:6240
Deposited By:IoN
Deposited On:13 Aug 2009 14:02
Last Modified:13 Aug 2009 14:02

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