He, Jin and Lin, Lisha and Zhang, Peirning and Lindsay, Stuart (2007) Identification of DNA basepairing via tunnel-current decay. NANO LETTERS, 7 (12). pp. 3854-3858.
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Official URL: http://pubs.acs.org/doi/abs/10.1021/nl0726205
We propose a new approach for reading the sequence of a DNA molecule passing between electrodes on a nanopore, using hydrogen bond-mediated tunneling signals. The base-electrode interaction is modeled using a nucleo-base-functionalized STM probe that is pulled away from a nucleoside monolayer. Watson−Crick recognition results in slow decay of the tunnel current, which is uniquely characteristic of the basepair in over half the reads. Thirteen independent reads would yield the desired 99.99% accuracy.
|Subjects:||Biomedical Science > Nanomedicine|
|Deposited On:||13 Aug 2009 14:09|
|Last Modified:||13 Aug 2009 14:09|
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