He, Jin and Lin, Lisha and Zhang, Peirning and Lindsay, Stuart (2007) Identification of DNA basepairing via tunnel-current decay. NANO LETTERS, 7 (12). pp. 3854-3858.
Full text is not hosted in this archive but may be available via the Official URL, or by requesting a copy from the corresponding author.
Official URL: http://pubs.acs.org/doi/abs/10.1021/nl0726205
Abstract
We propose a new approach for reading the sequence of a DNA molecule passing between electrodes on a nanopore, using hydrogen bond-mediated tunneling signals. The base-electrode interaction is modeled using a nucleo-base-functionalized STM probe that is pulled away from a nucleoside monolayer. Watson−Crick recognition results in slow decay of the tunnel current, which is uniquely characteristic of the basepair in over half the reads. Thirteen independent reads would yield the desired 99.99% accuracy.
| Item Type: | Article |
|---|---|
| Subjects: | Biomedical Science > Nanomedicine |
| ID Code: | 6238 |
| Deposited By: | IoN |
| Deposited On: | 13 Aug 2009 14:09 |
| Last Modified: | 13 Aug 2009 14:09 |
Repository Staff Only: item control page
