Nano Archive

Identification of DNA basepairing via tunnel-current decay

He, Jin and Lin, Lisha and Zhang, Peirning and Lindsay, Stuart (2007) Identification of DNA basepairing via tunnel-current decay. NANO LETTERS, 7 (12). pp. 3854-3858.

Full text is not hosted in this archive but may be available via the Official URL, or by requesting a copy from the corresponding author.

Official URL: http://pubs.acs.org/doi/abs/10.1021/nl0726205

Abstract

We propose a new approach for reading the sequence of a DNA molecule passing between electrodes on a nanopore, using hydrogen bond-mediated tunneling signals. The base-electrode interaction is modeled using a nucleo-base-functionalized STM probe that is pulled away from a nucleoside monolayer. Watson−Crick recognition results in slow decay of the tunnel current, which is uniquely characteristic of the basepair in over half the reads. Thirteen independent reads would yield the desired 99.99% accuracy.

Item Type:Article
Subjects:Biomedical Science > Nanomedicine
ID Code:6238
Deposited By:IoN
Deposited On:13 Aug 2009 14:09
Last Modified:13 Aug 2009 14:09

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