Nano Archive

Single-pair FRET characterization of DNA tweezers

Mueller, Barbara K. and Reuter, Andreas and Simmel, Friedrich C. and Lamb, Don C. (2006) Single-pair FRET characterization of DNA tweezers. NANO LETTERS, 6 (12). pp. 2814-2820.

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The self-assembly properties of DNA make it an ideal choice for the construction of nanomachines such as DNA tweezers. Because nanomachines function as individual units, they need to be studied on the single-molecule level. From single-pair FRET investigations, we show that ``open'' tweezers exist in a single conformation with minimal FRET efficiency, whereas upon addition of a ``closing strand'', three conformations are observed, which are averaged out in ensemble measurements.

Item Type:Article
Uncontrolled Keywords:DNA - nanomachines - FRET - tweazers
Subjects:Biomedical Science > Nanobiotechnology
ID Code:6231
Deposited By:IoN
Deposited On:07 Sep 2009 13:43
Last Modified:07 Sep 2009 13:43

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