Nano Archive

RNA used to control a DNA rotary nanomachine

Zhong, Hong and Seeman, Nadrian C. (2006) RNA used to control a DNA rotary nanomachine. NANO LETTERS, 6 (12). pp. 2899-2903.

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The PX-JX(2) device is a robust sequence-dependent DNA nanomachine. It is controlled by the addition of DNA strands to the solution. The ability to control such devices with RNA will enable the machine to respond to signals generated by transcriptional logic circuits in vitro or, possibly, in vivo. The PX-JX(2) device does not respond properly to RNA strands, so we have adapted the signaling method by using a cover-strand strategy, This approach entails using DNA control strands that contain sequence regions to set the device to either state. An RNA strand is used to mask one of these two regions, enabling the machine to assume the state corresponding to the unmasked region.

Item Type:Article
Uncontrolled Keywords:DNA - logic circuits - nanomachines - RNA
Subjects:Biomedical Science > Nanobiotechnology
ID Code:6220
Deposited By:IoN
Deposited On:07 Sep 2009 14:27
Last Modified:07 Sep 2009 14:27

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