Beiner, M. and Rengarajan, G. T. and Pankaj, S. and Enke, D. and Steinhart, M. (2007) Manipulating the crystalline state of pharmaceuticals by nanoconfinement. NANO LETTERS, 7 (5). pp. 1381-1385.
Official URL: http://pubs.acs.org/doi/full/10.1021/nl0705081
We show that nanoconfinement is a handle to rationally produce and stabilize otherwise metastable or transient polymorphs of pharmaceuticals, as required for controllable and efficient drug delivery. The systematic investigation of crystallization under confinement unveils thermodynamic properties of metastable polymorphs not accessible otherwise and may enhance the understanding of the crystallization behavior of pharmaceuticals in general. As an example in this case, we studied acetaminophen confined to inexpensive and biocompatible nanoporous host systems. Calorimetric and X-ray scattering data clearly evidence that either the stable polymorph form I or the metastable polymorph form III can be stabilized in high yields. Thermodynamic parameters for form III of acetaminophen are reported, and strategies to manipulate the crystalline state in pores by thermal treatments are presented.
|Uncontrolled Keywords:||FORM-III; CONFINEMENT; PARACETAMOL; BEHAVIOR; ACETAMINOPHEN; POLYMORPHISM; ALUMINA; SOLIDS; SCALE|
|Subjects:||Material Science > Nanostructured materials|
|Deposited On:||08 Sep 2009 11:33|
|Last Modified:||08 Sep 2009 11:33|
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