Lee, Seung-Jun and Anandan, Venkataramani and Zhang, Guigen (2007) Electrochemical fabrication and evaluation of highly sensitive nanorod-modified electrodes for a biotin/avidin system. BIOSENSORS & BIOELECTRONICS, 23 (7). pp. 1117-1124.
Full text is not hosted in this archive but may be available via the Official URL, or by requesting a copy from the corresponding author.
Official URL: http://www.sciencedirect.com/science?_ob=ArticleUR...
Bioaffinity sensors need to be rapid, specific, and highly sensitive. To realize these features, electrodes that can elicit high electrochemical performance are necessary. In this study, we developed nanorod array electrode and performed cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) experiments to study the interfacial properties of the nanorod array electrode with Fe(CN)6 3−/4− as the redox molecules. Results showed that both the CV and EIS measurements captured very well the resistive and capacitive changes due to the adsorption of functionalizing molecules and the coupling between avidin and biotin. The EIS measurements were more sensitive in discriminating small changes caused by the surface adsorption of various molecules. The use of avidin-functionalized gold nanorod modified electrodes had led to much increased detection sensitivity along with a detection-limit as low as 1 ng/mL of biotin.
|Uncontrolled Keywords:||nanorod electrodes; bioaffinity; avidintbiotin; cyclic voltammetry; electrochemical impedance spectroscopy|
|Subjects:||Analytical Science > Nanotechnology for sensing and actuating|
Biomedical Science > Nanotechnology for human health
|Deposited On:||04 Aug 2009 16:58|
|Last Modified:||04 Aug 2009 16:58|
Repository Staff Only: item control page