Nano Archive

Elemental selenium at nano size (Nano-Se) as a potential chemopreventive agent with reduced risk of selenium toxicity: Comparison with Se-methylselenocysteine in mice

Zhang, Jinsong and Wang, Xufang and Xu, Tongwen (2008) Elemental selenium at nano size (Nano-Se) as a potential chemopreventive agent with reduced risk of selenium toxicity: Comparison with Se-methylselenocysteine in mice. TOXICOLOGICAL SCIENCES, 101 (1). pp. 22-31. ISSN Online ISSN 1096-0929 - Print ISSN 1096-6080

Full text is not hosted in this archive but may be available via the Official URL, or by requesting a copy from the corresponding author.

Official URL: http://toxsci.oxfordjournals.org/cgi/content/abstr...

Abstract

Selenium (Se) is an essential trace element with a narrow margin between beneficial and toxic effects. As a promising chemopreventive agent, its use requires consumption over the long term, so the toxicity of Se is always a crucial concern. Based on clinical findings and recent studies in selenoprotein gene-modified mice, it is likely that the antioxidant function of one or more selenoprotcins is responsible for the chemopreventive effect of Se. Furthermore, upregulation of phase 2 enzymes by Se has been implicated as a possible chernopreventive mechanism at supra-nutritional dietary levels. Se-methylselenocysteine (SeMSC), a naturally occurring organic Se product, is considered as one of the most effective chernopreventive selenocompounds. The present study revealed that, as compared with SeMSC, elemental Se at nano size (Nano-Se) possessed equal efficacy in increasing the activities of glutathione peroxidase, thioredoxin reductase, and glutathione S-transferase, but had much lower toxicity as indicated by median lethal dose, acute liver injury, survival rate, and short-term toxicity. Our results suggest that Nano-Se can serve as a potential chernopreventive agent with reduced risk of Se toxicity.

Item Type:Article
Uncontrolled Keywords:Nano-Se; Se-methylselenocysteine; toxicity; bioavailability; selenoenzymes; glutathione S-transferase
Subjects:Biomedical Science > Nanomedicine
ID Code:604
Deposited By:M T V
Deposited On:10 Dec 2008 09:13
Last Modified:10 Dec 2008 09:13

Repository Staff Only: item control page