Zhang, Jinsong and Wang, Xufang and Xu, Tongwen (2008) Elemental selenium at nano size (Nano-Se) as a potential chemopreventive agent with reduced risk of selenium toxicity: Comparison with Se-methylselenocysteine in mice. TOXICOLOGICAL SCIENCES, 101 (1). pp. 22-31. ISSN Online ISSN 1096-0929 - Print ISSN 1096-6080
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Official URL: http://toxsci.oxfordjournals.org/cgi/content/abstr...
Selenium (Se) is an essential trace element with a narrow margin between beneficial and toxic effects. As a promising chemopreventive agent, its use requires consumption over the long term, so the toxicity of Se is always a crucial concern. Based on clinical findings and recent studies in selenoprotein gene-modified mice, it is likely that the antioxidant function of one or more selenoprotcins is responsible for the chemopreventive effect of Se. Furthermore, upregulation of phase 2 enzymes by Se has been implicated as a possible chernopreventive mechanism at supra-nutritional dietary levels. Se-methylselenocysteine (SeMSC), a naturally occurring organic Se product, is considered as one of the most effective chernopreventive selenocompounds. The present study revealed that, as compared with SeMSC, elemental Se at nano size (Nano-Se) possessed equal efficacy in increasing the activities of glutathione peroxidase, thioredoxin reductase, and glutathione S-transferase, but had much lower toxicity as indicated by median lethal dose, acute liver injury, survival rate, and short-term toxicity. Our results suggest that Nano-Se can serve as a potential chernopreventive agent with reduced risk of Se toxicity.
|Uncontrolled Keywords:||Nano-Se; Se-methylselenocysteine; toxicity; bioavailability; selenoenzymes; glutathione S-transferase|
|Subjects:||Biomedical Science > Nanomedicine|
|Deposited By:||M T V|
|Deposited On:||10 Dec 2008 09:13|
|Last Modified:||10 Dec 2008 09:13|
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