Nano Archive

Effect of particle dimension on biocompatibility of carbon nanomaterials

Grabinski, Christin and Hussain, Saber and Lafdi, Khalid and Braydich-Stolle, Laura K. and Schlager, John (2007) Effect of particle dimension on biocompatibility of carbon nanomaterials. CARBON, 45 (14). pp. 2828-2835. ISSN 0008-6223

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With various emerging applications ranging from medicine to materials and electronics, the risk of exposure to nanomaterials is rapidly increasing. Several routes of exposure to nanomaterials exist; the most important being dermal contact and inhalation. In this dermal toxicity study, the cellular effects of carbon-based materials with diameters ranging from micro- to nano-dimension were investigated using mouse keratinocytes (HEL-30). The carbon materials tested included carbon fibers (CF; 10 mu m, diameter), carbon nanofibers (CNF; 100 nm diameter), multi-walled carbon nanotubes (MWCNT; 10 nm diameter), and single-walled carbon nanotubes (SWCNT; 1 nm diameter). CF and CNF did not significantly affect cell viability; however, MWCNT and SWCNT reduced cell viability in a time-dependent manner up to 48 h, with full recovery of mitochondrial function by the 72 h time point. After a 24 h exposure, cells exposed to MWCNT produced up to 3-fold higher increase in reactive oxygen species than those exposed to SWCNT. The results of this study suggest that high-aspect ratio carbon material toxicity is dependent on dimension and composition. (C) 2007 Elsevier Ltd. All rights reserved.

Item Type:Article
Subjects:NanoSafety > Environment, health and safety aspects of nanotechnology
ID Code:603
Deposited By:M T V
Deposited On:10 Dec 2008 09:30
Last Modified:12 Feb 2009 09:44

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