Grabinski, Christin and Hussain, Saber and Lafdi, Khalid and Braydich-Stolle, Laura K. and Schlager, John (2007) Effect of particle dimension on biocompatibility of carbon nanomaterials. CARBON, 45 (14). pp. 2828-2835. ISSN 0008-6223
Full text is not hosted in this archive but may be available via the Official URL, or by requesting a copy from the corresponding author.
With various emerging applications ranging from medicine to materials and electronics, the risk of exposure to nanomaterials is rapidly increasing. Several routes of exposure to nanomaterials exist; the most important being dermal contact and inhalation. In this dermal toxicity study, the cellular effects of carbon-based materials with diameters ranging from micro- to nano-dimension were investigated using mouse keratinocytes (HEL-30). The carbon materials tested included carbon fibers (CF; 10 mu m, diameter), carbon nanofibers (CNF; 100 nm diameter), multi-walled carbon nanotubes (MWCNT; 10 nm diameter), and single-walled carbon nanotubes (SWCNT; 1 nm diameter). CF and CNF did not significantly affect cell viability; however, MWCNT and SWCNT reduced cell viability in a time-dependent manner up to 48 h, with full recovery of mitochondrial function by the 72 h time point. After a 24 h exposure, cells exposed to MWCNT produced up to 3-fold higher increase in reactive oxygen species than those exposed to SWCNT. The results of this study suggest that high-aspect ratio carbon material toxicity is dependent on dimension and composition. (C) 2007 Elsevier Ltd. All rights reserved.
|Subjects:||NanoSafety > Environment, health and safety aspects of nanotechnology|
|Deposited By:||M T V|
|Deposited On:||10 Dec 2008 09:30|
|Last Modified:||12 Feb 2009 09:44|
Repository Staff Only: item control page