Nano Archive

Detection of DNA sequences using an alternating electric field in a nanopore capacitor

Sigalov, Grigori and Comer, Jeffrey and Timp, Gregory and Aksimentiev, Aleksei (2008) Detection of DNA sequences using an alternating electric field in a nanopore capacitor. NANO LETTERS, 8 (1). pp. 56-63.

Full text is not hosted in this archive but may be available via the Official URL, or by requesting a copy from the corresponding author.

Official URL: http://pubs.acs.org/doi/full/10.1021/nl071890k

Abstract

Molecular dynamics simulations revealed that back-and-forth motion of DNA strands through a 1 nm diameter pore exhibits sequence-specific hysteresis that arises from the reorientation of the DNA bases in the nanopore constriction. Such hysteresis of the DNA motion results in detectable changes of the electrostatic potential at the electrodes of the nanopore capacitor and in a sequence-specific drift of the DNA strand under an oscillating transmembrane bias. A strategy is suggested for sequencing DNA in a nanopore using the electric field that alternates periodically in time.

Item Type:Article
Uncontrolled Keywords:NANOMETER-DIAMETER PORE; SOLID-STATE NANOPORES; SINGLE-STRANDED-DNA; SYNTHETIC NANOPORE; MEMBRANE CHANNEL; NUCLEIC-ACIDS; HUMAN GENOME; MOLECULES; TRANSPORT; DISCRIMINATION
Subjects:Biomedical Science > Nanobiotechnology
ID Code:5986
Deposited By:IoN
Deposited On:16 Sep 2009 10:05
Last Modified:16 Sep 2009 10:05

Repository Staff Only: item control page