Sigalov, Grigori and Comer, Jeffrey and Timp, Gregory and Aksimentiev, Aleksei (2008) Detection of DNA sequences using an alternating electric field in a nanopore capacitor. NANO LETTERS, 8 (1). pp. 56-63.
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Official URL: http://pubs.acs.org/doi/full/10.1021/nl071890k
Molecular dynamics simulations revealed that back-and-forth motion of DNA strands through a 1 nm diameter pore exhibits sequence-specific hysteresis that arises from the reorientation of the DNA bases in the nanopore constriction. Such hysteresis of the DNA motion results in detectable changes of the electrostatic potential at the electrodes of the nanopore capacitor and in a sequence-specific drift of the DNA strand under an oscillating transmembrane bias. A strategy is suggested for sequencing DNA in a nanopore using the electric field that alternates periodically in time.
|Uncontrolled Keywords:||NANOMETER-DIAMETER PORE; SOLID-STATE NANOPORES; SINGLE-STRANDED-DNA; SYNTHETIC NANOPORE; MEMBRANE CHANNEL; NUCLEIC-ACIDS; HUMAN GENOME; MOLECULES; TRANSPORT; DISCRIMINATION|
|Subjects:||Biomedical Science > Nanobiotechnology|
|Deposited On:||16 Sep 2009 10:05|
|Last Modified:||16 Sep 2009 10:05|
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