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High efficient electrical stimulation of hippocampal slices with vertically aligned carbon nanofiber microbrush array

de Asis, Edward D. and Nguyen-Vu, T. D. Barbara and Arumugam, Prabhu U. and Chen, Hua and Cassell, Alan M. and Andrews, Russell J. and Yang, Cary Y. and Li, Jun (2009) High efficient electrical stimulation of hippocampal slices with vertically aligned carbon nanofiber microbrush array. Biomedical Microdevices, 11 (4). pp. 801-808.

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Official URL: http://www.springerlink.com/content/h36m5112jg0t27...

Abstract

Long-term neuroprostheses for functional electrical stimulation must efficiently stimulate tissue without electrolyzing water and raising the extracellular pH to toxic levels. Comparison of the stimulation efficiency of tungsten wire electrodes (W wires), platinum microelectrode arrays (PtMEA), as-grown vertically aligned carbon nanofiber microbrush arrays (VACNF MBAs), and polypyrrole coated (PPy-coated) VACNF MBAs in eliciting field potentials in the hippocampus slice indicates that, at low stimulating voltages that preclude the electrolysis of water, only the PPy-coated VACNF MBA is able to stimulate the CA3 to CA1 pathway. Unlike the W wires, PtMEA, as-grown VACNF MBA, and the PPy-coated VACNF MBA elicit only excitatory postsynaptic potentials (EPSPs). Furthermore, the PPy-coated VACNF MBA evokes somatic action potentials in addition to EPSPs. These results highlight the PPy-coated VACNF’s advantages in lower electrode impedance, ability to stimulate tissue through a biocompatible chloride flux, and stable vertical alignment in liquid that enables access to spatially confined regions of neuronal cells.

Item Type:Article
Subjects:Biomedical Science > Nanoscale biological processes
Biomedical Science > Nanobiotechnology
Biomedical Science > Nanomedicine
ID Code:5853
Deposited By:IoN
Deposited On:29 Jul 2009 16:27
Last Modified:29 Jul 2009 16:27

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