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Fabrication of orderly nanostructured PLGA scaffolds using anodic aluminum oxide templates

Wang, Gou-Jen and Lin, Yan-Cheng and Li, Ching-Wen and Hsueh, Cheng-Chih and Hsu, Shan-hui and Hung, Huey-Shan (2009) Fabrication of orderly nanostructured PLGA scaffolds using anodic aluminum oxide templates. Biomedical Microdevices, 11 (4). pp. 843-850.

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Official URL: http://www.springerlink.com/content/q8hg561076m593...

Abstract

In this research, two simple fabrication methods to fabricate orderly nanostructured PLGA scaffolds using anodic aluminum oxide (AAO) template were conducted. In the vacuum air-extraction approach, the PLGA solution was cast on an AAO template first. The vacuum air-extraction process was then applied to suck the semi-congealed PLGA into the nanopores of the AAO template to form a bamboo sprouts array of PLGA. The surface roughness of the nanostructured scaffolds, ranging from 20 nm to 76 nm, can be controlled by the sucking time of the vacuum air-extraction process. In the replica molding approach, the PLGA solution was cast on the orderly scraggy barrier-layer surface of an AAO membrane to fabricate a PLGA scaffold of concave nanostructure. Cell culture experiments using the bovine endothelial cells (BEC) demonstrated that the nanostructured PLGA membrane can increase the cell growing rate, especially for the bamboo sprouts array scaffolds with smaller surface roughness.

Item Type:Article
Subjects:Biomedical Science > Nanoscale biological processes
Biomedical Science > Nanotechnology for human health
ID Code:5848
Deposited By:IoN
Deposited On:04 Aug 2009 16:51
Last Modified:04 Aug 2009 16:51

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