Nano Archive

Miscellaneous nanoaggregates made of [beta]-CD esters synthesised by an enzymatic pathway

Choisnard, L and Gèze, A and Yaméogo, B. G. J. and Putaux, J. -L. and Wouessidjewe, D (2007) Miscellaneous nanoaggregates made of [beta]-CD esters synthesised by an enzymatic pathway. International Journal of Pharmaceutics, 344 (1-2). 26 - 32.

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Various β-cyclodextrin (β-CD) fatty esters with different chain lengths (C4–C14) were synthesised by transesterification of β-cyclodextrin by vinyl fatty ester using thermolysin in DMSO. For each cyclodextrin derivatives, two batches of synthesis were realized. The ability of these derivatives to form nano-organized systems was investigated through the solvent displacement technique. During the formulation step, the effects of the initial concentration of β-CD fatty esters in the organic phase and that of the final volume of the aqueous non-solvent phase were studied. Except for the β-CD C4 ester, the transesterified β-CD derivatives led to measurable nanoparticles. Cryo-electron microscopy images showed a significant morphological variability. Spherical, rod-like or more irregularly-shaped nano-objects were observed with either matricial or lamellar structures. A statistical analysis by a two-way ANOVA was computed for each class of β-cyclodextrin esters in order to determine the effects of batch and formulation on the final size of nanoparticles.

Item Type:Article
Additional Information:New Trends in Drug Delivery Systems
Uncontrolled Keywords:Thermolysin transesterification; β-cyclodextrin fatty esters; Nanosystems; Quasi-elastic light scattering; Cryo-transmission electron microscopy; Variance analysis
Subjects:Material Science > Nanofabrication processes and tools
Material Science > Nanostructured materials
Biomedical Science > Nanomedicine
ID Code:5824
Deposited By:SPI
Deposited On:07 Jul 2009 16:38
Last Modified:07 Jul 2009 16:38

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