Nano Archive

Efficiency of Nano-Electrospray Ionization

El-Faramawy, Ayman and Siu, K. W. Michael and Thomson, Bruce A. (2005) Efficiency of Nano-Electrospray Ionization. Journal of the American Society for Mass Spectrometry, 16 (10). 1702 - 1707.

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The efficiency of nano-electrospray ionization, defined as the flux of ions reaching the detector of a triple-quadrupole mass spectrometer divided by the flux of analyte ions leaving the needle, has been measured in a series of controlled experiments with dodecyltrimethyl ammonium (DDTMA) bromide, myoglobin, Glu- [1]-fibrinopeptide, and gramicidin S. By varying the flow rate from each needle, the optimum efficiency was determined. In general, the efficiency increased as the flow rate decreased. For DDTMA, efficiencies of up to 12% were measured, although efficiencies of 1% were more common. Ion current measurements indicated efficient transfer of ions from the needle through to the detector. Significant needle-to-needle variations in efficiency were encountered and attributed to variations in ion-generation efficiency.

Item Type:Article
Subjects:Material Science > Nanofabrication processes and tools
Biomedical Science > Nanomedicine
ID Code:5808
Deposited By:SPI
Deposited On:07 Jul 2009 17:33
Last Modified:07 Jul 2009 17:33

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