Ueno, Y and Futagawa, H and Takagi, Y and Ueno, A and Mizushima, Y (2005) Drug-incorporating calcium carbonate nanoparticles for a new delivery system. Journal of Controlled Release, 103 (1). 93 - 98.
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Official URL: http://www.sciencedirect.com/science/article/B6T3D...
We devised a simple method for incorporating drugs into solid calcium carbonate nanoparticles (nano-CaCO3). The size of nano-CaCO3 was controlled by mixing speed. Washing the nanoparticles released little incorporated drug but much drug that was adsorbed on the surface. In an in vitro releasing test, granulocyte colony-stimulating factor incorporated in nano-CaCO3 was chemically stable and released very slowly. Subcutaneous injection of nano-CaCO3 incorporating betamethasone phosphate (BP) resulted in a smaller initial increase in plasma concentration and a subsequent sustained release in compared with betamethasone phosphate solution. Nano-CaCO3 may be useful to deliver hydrophilic drugs and bioactive proteins.
|Uncontrolled Keywords:||Nanoparticle; Calcium carbonate; CaCO3; DDS; Sustained release|
|Subjects:||Material Science > Nanofabrication processes and tools|
Biomedical Science > Nanomedicine
|Deposited On:||07 Jul 2009 17:42|
|Last Modified:||07 Jul 2009 17:42|
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