Carli, F and Chiellini, E. E. and Bellich, B and Macchiavelli, S and Cadelli, G (2005) Ubidecarenone nanoemulsified composite systems. International Journal of Pharmaceutics, 291 (1-2). 113 - 118.
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Official URL: http://www.sciencedirect.com/science/article/B6T7W...
The nanoemulsified composite (NEC™) delivery system is a patented technology based on the incorporation of a double microemulsion into microporous carrier. This approach was applied on the very water insoluble ubidecarenone drug. The resulting composite powder showed good technological properties such as flowability; also good stability was evidentiated, with size of the nano-droplets released from the systems maintained equal to the starting size also after a long storage. Furthermore very good biopharmaceutical properties were originated, with water solubility concentrations up to 50-fold higher than pure ubidecarenone and oral absorption in rats up to three-fold greater than standard commercial products in terms of plasma levels and AUC.
|Additional Information:||Proceedings of the 5th Central European Symposium on Pharmaceutical Technology and Biotechnology|
|Uncontrolled Keywords:||Solid double microemulsion; Coenzyme Q10; Oral absorption; Sub-micron droplets; Stability|
|Subjects:||Biomedical Science > Nanomedicine|
|Deposited On:||07 Jul 2009 17:44|
|Last Modified:||07 Jul 2009 17:44|
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