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A subchronic toxicity study of elemental Nano-Se in Sprague-Dawley rats

Jia, X and Li, N and Chen, J (2005) A subchronic toxicity study of elemental Nano-Se in Sprague-Dawley rats. Life Sciences, 76 (17). 1989 - 2003.

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Official URL: http://www.sciencedirect.com/science/article/B6T99...

Abstract

The subchronic toxicity of Nano-Se was compared with selenite and high-selenium protein in rats. Groups of Sprague-Dawley rats (12 males and 12 females per group) were fed diets containing Nano-Se, selenite and high-selenium protein at concentrations of 0, 2, 3, 4 and 5 ppm Se, respectively, for 13 weeks. Clinical observations were made and body weight and food consumption were recorded weekly. At the end of the study, the rats were subjected to a full necropsy, blood samples were collected for hematology and clinical chemistry determination. Histopathological examination was performed on selected tissues. At the two higher doses (4 and 5 ppm Se), significant abnormal changes were found in body weight, hematology, clinical chemistry, relative organ weights and histopathology parameters. However, the toxicity was more pronounced in the selenite and high-selenium protein groups than the Nano-Se group. At the dose of 3 ppm Se, significant growth inhibition and degeneration of liver cells were found in the selenite and high-selenium protein groups. No changes attributable to administration of Nano-Se at the dose of 3 ppm Se were found. Taken together, the no-observed-adverse-effect level (NOAEL) of Nano-Se in male and female rats was considered to be 3 ppm Se, equivalent to 0.22 mg/kg bw/day for males and 0.33 mg/kg bw/day for females. On the other hand, the NOAELs of selenite and high-selenium protein in males and females were considered to be 2 ppm Se, equivalent to 0.14 mg/kg bw/day for males and 0.20 mg/kg bw/day for females. In addition, studies have shown that Nano-Se has a similar bioavailability in rat, and much less acute toxicity in mice compared with selenite. In conclusion, Nano-Se is less toxic than selenite and high-selenium protein in the 13-week rat study.

Item Type:Article
Uncontrolled Keywords:Toxicity; Nano-Se; Selenite; High-selenium protein
Subjects:NanoSafety > Environment, health and safety aspects of nanotechnology
Biomedical Science > Nanomedicine
ID Code:5802
Deposited By:SPI
Deposited On:07 Jul 2009 17:46
Last Modified:07 Jul 2009 17:46

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