Nano Archive

Successful treatment of photo-damaged skin of nano-scale atRA particles using a novel transdermal delivery

Yamaguchi, Yoko and Nagasawa, Teruaki and Nakamura, Natsumi and Takenaga, Mitsuko and Mizoguchi, Masako and Kawai, Shin-ichi and Mizushima, Yutaka and Igarashi, Rie (2005) Successful treatment of photo-damaged skin of nano-scale atRA particles using a novel transdermal delivery. Journal of Controlled Release, 104 (1). 29 - 40.

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We show a novel drug delivery system (DDS) for improved all-trans retinoic acid (atRA) therapy for external treatments of photo-damaged skin. We prepared inorganic-coated atRA nanoparticles, in turn an egg-like structure in nano-scale (Nano-atRA), using boundary-organized reaction droplets. The interfacial properties of organic architectures, in atRA micelles, were used to template the nucleation of inorganic minerals. As a result, irritation and inflammation associated with atRA therapy were substantially reduced due to the complete encapsulation of the carboxylic function. Both irritative symptoms and physicochemical instability of the atRA micelle were improved. Since Nano-atRA which is prepared following to this new DDS system developmentally improved the permeability to the stratum corneum, the remarkable pharmacological effects were resulted in comparison with atRA as such as follows: (1) thicker epidermis than classical atRA treatment and (2) the overexpression of mRNA for heparin-binding epidermal growth factor (HB-EGF) as the provocation epidermal hyperplasia. Furthermore, we found a surprising boost in production of hyaluronan (HA) among the intercellular spaces of the basal and spinous cell layers in epidermis. Nano-atRA technology for atRA therapy could not only efficiently regulate keratinocyte cell proliferation and differentiation, but also markedly produce the additional benefit. Severely injured human skin by chronic ultraviolet irradiation will completely repair due to the accelerated turnover of skin tissue, which is induced by Nano-atRA.

Item Type:Article
Uncontrolled Keywords:All-trans retinoic acid (atRA); Micelle; Core-shell structure; Epidermis; HB-EGF; Hyaluronan (HA); Inorganic material
Subjects:Material Science > Nanofabrication processes and tools
Material Science > Nanostructured materials
Biomedical Science > Nanomedicine
ID Code:5798
Deposited By:SPI
Deposited On:07 Jul 2009 17:55
Last Modified:07 Jul 2009 17:55

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