Perrut, M and Jung, J and Leboeuf, F (2005) Enhancement of dissolution rate of poorly-soluble active ingredients by supercritical fluid processes: Part I: Micronization of neat particles. International Journal of Pharmaceutics, 288 (1). 3 - 10.
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Official URL: http://www.sciencedirect.com/science/article/B6T7W...
In this first of two articles, we discuss some issues surrounding the dissolution rate enhancement of poorly-soluble active ingredients micronized into nano-particles using several supercritical fluid particle design processes including rapid expansion of supercritical solutions (RESS), supercritical anti-solvent (SAS) and particles from gas-saturated solutions/suspensions (PGSS). Experimental results confirm that dissolution rates do not only depend on the surface area and particle size of the processed powder, but are greatly affected by other physico-chemical characteristics such as crystal morphology and wettability that may reduce the benefit of micronization.
|Uncontrolled Keywords:||Particle design; Supercritical fluid; Dissolution enhancement; Micronization; Nanoparticles; Microspheres|
|Subjects:||Biomedical Science > Nanomedicine|
|Deposited On:||23 Jul 2009 17:56|
|Last Modified:||23 Jul 2009 17:56|
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