Nano Archive

Label-free direct electronic detection of biomolecules with amorphous silicon nanostructures

Lund, John and Mehta, Ranjana and Parviz, Babak A. (2006) Label-free direct electronic detection of biomolecules with amorphous silicon nanostructures. Nanomedicine: Nanotechnology, Biology and Medicine, 2 (4). 230 - 238.

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We present the fabrication and characterization of a nano-scale sensor made of amorphous silicon for the label-free, electronic detection of three classes of biologically important molecules: ions, oligonucleotides, and proteins. The sensor structure has an active element which is a 50 nm wide amorphous silicon semicircle and has a total footprint of less than 4 μm2. We demonstrate the functionalization of the sensor with receptor molecules and the electronic detection of three targets: H+ ions, short single-stranded DNAs, and streptavidin. The sensor is able to reliably distinguish single base-pair mismatches in 12 base long strands of DNA and monitor the introduction and identification of straptavidin in real-time. The versatile sensor structure can be readily functionalized with a wide range of receptor molecules and is suitable for integration with high-speed electronic circuits as a post-process on an integrated circuit chip.

Item Type:Article
Uncontrolled Keywords:Nano-scale sensing; Electronic detection; Label-free sensing; Amorphous silicon nanostructure; DNA
Subjects:Material Science > Nanofabrication processes and tools
Analytical Science > Nanotechnology for sensing and actuating
Biomedical Science > Nanomedicine
ID Code:5746
Deposited By:SPI
Deposited On:24 Jul 2009 10:30
Last Modified:24 Jul 2009 10:30

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