Nano Archive

Nano hemostat solution: immediate hemostasis at the nanoscale

Ellis-Behnke, Rutledge G. and Liang, Yu-Xiang and Tay, David K.C. and Kau, Phillis W.F. and Schneider, Gerald E. and Zhang, Shuguang and Wu, Wutian and So, Kwok-Fai (2006) Nano hemostat solution: immediate hemostasis at the nanoscale. Nanomedicine: Nanotechnology, Biology and Medicine, 2 (4). 207 - 215.

Full text is not hosted in this archive but may be available via the Official URL, or by requesting a copy from the corresponding author.

Official URL: http://www.sciencedirect.com/science/article/B7MDB...

Abstract

Hemostasis is a major problem in surgical procedures and after major trauma. There are few effective methods to stop bleeding without causing secondary damage. We used a self-assembling peptide that establishes a nanofiber barrier to achieve complete hemostasis immediately when applied directly to a wound in the brain, spinal cord, femoral artery, liver, or skin of mammals. This novel therapy stops bleeding without the use of pressure, cauterization, vasoconstriction, coagulation, or cross-linked adhesives. The self-assembling solution is nontoxic and nonimmunogenic, and the breakdown products are amino acids, which are tissue building blocks that can be used to repair the site of injury. Here we report the first use of nanotechnology to achieve complete hemostasis in less than 15 seconds, which could fundamentally change how much blood is needed during surgery of the future.

Item Type:Article
Uncontrolled Keywords:Hemostasis; Surgery; Trauma; Nanotechnology; Self-assembling peptide
Subjects:Material Science > Nanofabrication processes and tools
Biomedical Science > Nanomedicine
ID Code:5745
Deposited By:SPI
Deposited On:24 Jul 2009 10:35
Last Modified:24 Jul 2009 10:35

Repository Staff Only: item control page