Nano Archive

Dexamethasone nano-aggregates composed of PEG-PLA-PEG triblock copolymers for anti-proliferation of smooth muscle cells

Park, Tae Gwan and Yoo, Hyuk Sang (2006) Dexamethasone nano-aggregates composed of PEG-PLA-PEG triblock copolymers for anti-proliferation of smooth muscle cells. International Journal of Pharmaceutics, 326 (1-2). 169 - 173.

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Official URL: http://www.sciencedirect.com/science/article/B6T7W...

Abstract

Dexamethasone nano-aggregate was prepared for the treatment of intimal hyperplasia caused by abnormal proliferation of smooth muscle cells. Triblock copolymers composed of poly(ethylene glycol) [PEG] and poly(d,l-lactic acid) [PLA] were synthesized with different chain lengths of PEG. Triblock copolymers in organic phase were mixed with dexamethasone and dexamethasone nano-aggregates was prepared by dispersing the organic phase into water. The average diameter of the nano-aggregates ranged from 200 to 300 nm. Dexamethasone was released out from the nano-aggregates and the release profile was dependent on PEG chain lengths. The dexamethasone nano-aggregates showed superior anti-proliferation effects on smooth muscle cells compared to dexamethasone. Flow cytometry showed that smooth muscle cells treated with dexamethasone nano-aggregates was arrested at a dormant phase in a dose-dependent manner. The dexamethasone nano-aggregates are expected to be a potent candidate for anti-proliferating smooth muscle tissues after a balloon-catheter treatment.

Item Type:Article
Uncontrolled Keywords:Dexamethasone; Nano-aggregate; Smooth muscle cell; Anti-proliferation
Subjects:Biomedical Science > Nanomedicine
ID Code:5743
Deposited By:SPI
Deposited On:24 Jul 2009 10:41
Last Modified:24 Jul 2009 10:41

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