Nano Archive

Glycoproteomics: Past, present and future

Morris, Howard R. and Chalabi, Sara and Panico, Maria and Sutton-Smith, Mark and Clark, Gary F. and Goldberg, David and Dell, Anne (2007) Glycoproteomics: Past, present and future. International Journal of Mass Spectrometry, 259 (1-3). 16 - 31.

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Official URL: http://www.sciencedirect.com/science/article/B6VND...

Abstract

This invited paper charts the origins and progress of glycoproteomics mass spectrometry research at Imperial College, and in celebration of Donald Hunt's 65th birthday it puts into perspective some of the scientific influence which each group has had on the other over a period of some 35 years. We then describe and illustrate current nano-LC–ES–MS and MS/MS strategies for the structural assignment of N-linked glycosylation in proteins involved in sperm/egg fertilisation. Finally, we present recent progress in the automated interpretation of these glycopeptide data sets, which promises to supersede manual interpretation for many applications.

Item Type:Article
Additional Information:Donald F. Hunt Honour Issue
Uncontrolled Keywords:This invited paper charts the origins and progress of glycoproteomics mass spectrometry research at Imperial College, and in celebration of Donald Hunt's 65th birthday it puts into perspective some of the scientific influence which each group has had on the other over a period of some 35 years. We then describe and illustrate current nano-LC–ES–MS and MS/MS strategies for the structural assignment of N-linked glycosylation in proteins involved in sperm/egg fertilisation. Finally, we present recent progress in the automated interpretation of these glycopeptide data sets, which promises to supersede manual interpretation for many applications. Glycoproteomics; Mass spectrometry; Peptide sequencing; Carbohydrate sequencing; ZP3
Subjects:Biomedical Science > Nanomedicine
ID Code:5740
Deposited By:SPI
Deposited On:24 Jul 2009 15:14
Last Modified:24 Jul 2009 15:14

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