Nano Archive

Acute toxicity and biodistribution of different sized titanium dioxide particles in mice after oral administration

Wang, Jiangxue and Zhou, Guoqiang and Chen, Chunying and Yu, Hongwei and Wang, Tiancheng and Ma, Yongmei and Jia, Guang and Gao, Yuxi and Li, Bai and Sun, Jin and Li, Yufeng and Jiao, Fang and Zhao, Yuliang and Chai, Zhifang (2007) Acute toxicity and biodistribution of different sized titanium dioxide particles in mice after oral administration. Toxicology Letters, 168 (2). 176 - 185.

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In order to evaluate the toxicity of TiO2 particles, the acute toxicity of nano-sized TiO2 particles (25 and 80 nm) on adult mice was investigated compared with fine TiO2 particles (155 nm). Due to the low toxicity, a fixed large dose of 5 g/kg body weight of TiO2 suspensions was administrated by a single oral gavage according to the OECD procedure. In 2 weeks, TiO2 particles showed no obvious acute toxicity. However, the female mice showed high coefficients of liver in the nano-sized (25 and 80 nm) groups. The changes of serum biochemical parameters (ALT/AST, LDH) and pathology (hydropic degeneration around the central vein and the spotty necrosis of hepatocytes) of liver indicated that the hepatic injury was induced after exposure to mass different-sized TiO2 particles. In addition, the nephrotoxicity like increased BUN level and pathology change of kidneys was also observed in the experimental groups. The significant change of serum LDH and alpha-HBDH in 25 and 80 nm groups showed the myocardial damage compared with the control group. However, there are no abnormal pathology changes in the heart, lung, testicle (ovary), and spleen tissues. Biodistribution experiment showed that TiO2 mainly retained in the liver, spleen, kidneys, and lung tissues, which indicated that TiO2 particles could be transported to other tissues and organs after uptake by gastrointestinal tract.

Item Type:Article
Uncontrolled Keywords:Acute toxicity; Fixed dose procedure; Titanium dioxide; Nanoparticles; Mice
Subjects:NanoSafety > Environment, health and safety aspects of nanotechnology
ID Code:5737
Deposited By:SPI
Deposited On:24 Jul 2009 15:30
Last Modified:24 Jul 2009 15:30

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