Nano Archive

Synthesis and characterization of poly (amino ester) for slow biodegradable gene delivery vector

Kim, Hyun Jin and Kwon, Min Sung and Choi, Joon Sig and Kim, Bo Hye and Yoon, Jae Keun and Kim, Kwan and Park, Jong-sang (2007) Synthesis and characterization of poly (amino ester) for slow biodegradable gene delivery vector. Bioorganic & Medicinal Chemistry, 15 (4). 1708 - 1715.

Full text is not hosted in this archive but may be available via the Official URL, or by requesting a copy from the corresponding author.

Official URL: http://www.sciencedirect.com/science/article/B6TF8...

Abstract

Many therapeutic carrier materials were exploited for human gene therapy from viral to polymeric vectors. This research describes the evaluation of two biodegradable ester-bonded polymers synthesized by double-monomer polycondensation for a non-viral cationic polymer-based gene delivery system. The backbone was constructed to include inner tertiary amines and outer primary amines. Self-assembly with DNA resulted in the production of regularly nano-sized spherical polyplexes with good transfection efficiency, especially in the presence of serum. The polymers showed a relatively slow degradability for an amine-containing ester polymer, as they maintained DNA/polymer complex for 7 days in physiological buffer conditions. Finally, the low toxicity and slow degradation concluded these polymers reliable for long-term therapeutic applications.

Item Type:Article
Uncontrolled Keywords:Gene delivery; Biodegradable polymer; Ester polymer; DNA condensation; DNA delivery
Subjects:Biomedical Science > Nanomedicine
ID Code:5733
Deposited By:SPI
Deposited On:27 Jul 2009 09:41
Last Modified:27 Jul 2009 09:41

Repository Staff Only: item control page