Kim, Hyun Jin and Kwon, Min Sung and Choi, Joon Sig and Kim, Bo Hye and Yoon, Jae Keun and Kim, Kwan and Park, Jong-sang (2007) Synthesis and characterization of poly (amino ester) for slow biodegradable gene delivery vector. Bioorganic & Medicinal Chemistry, 15 (4). 1708 - 1715.
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Official URL: http://www.sciencedirect.com/science/article/B6TF8...
Many therapeutic carrier materials were exploited for human gene therapy from viral to polymeric vectors. This research describes the evaluation of two biodegradable ester-bonded polymers synthesized by double-monomer polycondensation for a non-viral cationic polymer-based gene delivery system. The backbone was constructed to include inner tertiary amines and outer primary amines. Self-assembly with DNA resulted in the production of regularly nano-sized spherical polyplexes with good transfection efficiency, especially in the presence of serum. The polymers showed a relatively slow degradability for an amine-containing ester polymer, as they maintained DNA/polymer complex for 7 days in physiological buffer conditions. Finally, the low toxicity and slow degradation concluded these polymers reliable for long-term therapeutic applications.
|Uncontrolled Keywords:||Gene delivery; Biodegradable polymer; Ester polymer; DNA condensation; DNA delivery|
|Subjects:||Biomedical Science > Nanomedicine|
|Deposited On:||27 Jul 2009 09:41|
|Last Modified:||27 Jul 2009 09:41|
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